Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives

<<< All content posted by permission of the DMCA. >>>

Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives download AZW3, ebooks download, read online, Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives by Laishram Rajendrakumar Singh

This book provides essential information on improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones and other chemical species. Therefore, subtle change in the composition of the environment will alter the protein folding process. The importance of the solvent environment in protein folding is precisely due to the fact that various disease-causing proteopathies can be reversed by manipulating the solvent environment of the malfolded proteins. Hostile environmental stresses represent one of the basic causes of such challenges in protein folding or misfolding. Since cells commonly encounter extreme environmental fluctuations, it is crucial that they equip themselves with strategies to circumvent the hostile environmental conditions. Nature has developed many strategies to ensure that the complex and challenging protein folding reaction occurs with adequate efficiency and fidelity for the success of the organism. Among the strategies employed in a wide range of species and cell types is the elaboration of small organic molecules called osmolytes. Additionally, recent advances have also revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and vaccine flocculation. In fact, a large pool of data has been generated regarding their potential for the therapeutic intervention of neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteostasis failure. Reflecting the multiple applications of these small molecules in the health and other industries, this book combines contributions by respected leaders in the field and will help to inspire college students, basic researchers, and clinicians to translate these biological roles of osmolytes into clinical practice. It will also shed light on some important future prospects of osmolytes like their role as drug excipients and provide a deeper understanding of their mechanism of action in the prevention of neuro-degenerative diseases.

Written by:

  • Author:
  • Publisher:Springer
  • Date postings: June 28, 2018
  • Cover:
  • Tongue: English
  • ISBN-10: 9811099472
  • ISBN-13: 978-9811099472
  • Dimensions:6.1 x 0.7 x 9.2 inches
  • Weight: 1.1 pounds
  • Pages:
  • Series:
  • Class:
  • Age:

Popular authors:

  • Author unknown Margaret Atwood Hoda Kotb Garth Stein Ta-Nehisi Coates Dav Pilkey Dan Bongino Ronan Farrow Garrett M. Graff Ryan Holiday Ann Patchett Ruth Ware IglooBooks The Law Library Alison Roman Michael Connelly Laura Lippman Elin Hilderbrand Elton John Tui T. Sutherland Bob Goff Alice Schertle Andrew Rea Gregg Jarrett John Sandford Susan Peirce Thompson Hannah Shaw Mes Mots de Passe Horko Jenny Clarkson That Random Gifts Chick Sonia Sotomayor Ibram X. Kendi Marty Smith Hillary Rodham Clinton Nathan W. Pyle Distinctive Journals Paul McCartney Mark Hyman Megan Miranda New York Times Tieghan Gerard Mason Landon Ray Dalio Wizards RPG Team John Grisham Jim Zub Timothy Zahn Lara Prescott Lee Child Deborah Lipstadt Bill O'Reilly Emma Walton Hamilton Lucasfilm Ltd James Patterson Bret Contreras Sandra Brown M. Shafiq Robert Crais Madonna Gauding Hunter Pollack Jonathan Cahn The Pokemon Company International Mirako Press Shea SERRANO Char story Rebekah Lyons Creative art planners 2019 Dr. Seuss Molly Elodie Rose Malcolm Gladwell David Baldacci Ree Drummond Ann M. Martin Flame Tree Studio Richard Russo Bret Baier Willow Creek Press Nora Roberts Doug Wead American Psychological Association Holly Black Mike Rowe Insight Editions D Duncan Lee Smith Character Notebooks Ben Horowitz Steven Heller Neal Shusterman Tim McGraw Carthography Planners Michael Bazzell Jojo Moyes Brian Kilmeade Hobby Notebooks P2G Comics Nicholas Lambert J.D. Robb Wild Pages Press Perfect Papers

  • Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives Book Reviews: